Biomaterials and Bioprinting

Biomaterials, particularly biodegradable polymers, comprise a rapidly evolving set of medical technologies with numerous applications. While medical implants made of metals or glass would permanently remain in the biological tissue if not removed surgically, biomedical nano/micro-devices made of biodegradable polymers would naturally degrade and disappear in tissue over a desired period of time, eliminating the need for an additional surgery for implant removal. As a leading research group in this area, we have been developing laser and UV light based 3D bioprinting techniques, including laser direct ablation, UV nanoimprinting, and stereolithography for biomaterials. We also investigate the mechanical, chemical and biological properties of such biomaterials and explore cell-material interactions through experiments and simulation. We have been creating 3D biomaterials with gradient of stiffness, Poisson's ratio, geometry, size, and growth factor. Our targeted applications are drug screening and tissue regeneration.

(Left) 3D Scaffolds with designer shapes fabricated by DMD-based 3D-printing, (middle) 3D-printing of vasculature in mere second, (right) auxetic scaffold with a negative Poisson's ratio.